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These findings indicate that antioxidant agents in the aqueous humor reflect glaucomatous optic nerve damage and that excessive oxidative stress may be involved in the pathogenesis of glaucoma

Michael J

van Antwerpen VL, Theron AJ, Richards GA, et al

Krishnamoorthy et al., 2024

Under normoxic cellular conditions, Nrf2 is bound by Kelch-like ECH-associated protein 1 (Keap1) and persists in an inactivated status through ubiquitination and degradation in the proteasome (Reisman et al., 2009)